Pancreatic Cancer Screening & Prevention

Overview

Information about the prevention of cancer and the science of screening appropriate individuals at high risk of developing cancer is gaining interest. Physicians and individuals alike recognize that the best “treatment” of cancer is preventing its occurrence in the first place or detecting it early when it may be most treatable.

Over the past several decades, the incidence of pancreatic cancer has been increasing and the disease is now the fifth leading cause of cancer death in the United States. Pancreatic cancer accounts for approximately 2% of all newly diagnosed cancers in the United States each year, but 5% of all cancer deaths. Pancreatic cancer is often called a silent killer because it usually does not cause any recognizable symptoms until it is advanced and has spread outside the pancreas. As a result, the majority of pancreatic cancers are not diagnosed until they have reached advanced stages and are considered incurable.

The chance of an individual developing cancer depends on both genetic and non-genetic factors. A genetic factor is an inherited, unchangeable trait, while a non-genetic factor is a variable in a person’s environment, which can often be changed. Non-genetic factors may include diet, exercise, or exposure to other substances present in our surroundings. These non-genetic factors are often referred to as environmental factors. Some non-genetic factors play a role in facilitating the process of healthy cells turning cancerous (i.e. the correlation between smoking and lung cancer) while other cancers have no known environmental correlation but are known to have a genetic predisposition, meaning a person may be at higher risk for a certain cancer if a family member has that type of cancer.

Heredity or Genetic Factors

Hereditary associations account for only a small fraction of the total number of cases of pancreatic cancer. Only 7 to 8% of patients with pancreatic cancer have one or more family members with pancreatic cancer. Some other inherited syndromes are associated with an increased incidence of pancreatic cancer, including familial adenomatous polyposis, familial atypical multiple mole melanoma and hereditary pancreatitis. Forty percent of patients with hereditary pancreatitis develop pancreatic cancer by the age of 70. The risk of developing pancreatic cancer is approximately 75% if the pattern of inheritance is through the father. Researchers have identified two gene mutations in families with hereditary pancreatitis. This discovery has helped to allow for screening in families with a history of familial pancreatitis.

Environmental or Non-Genetic Factors

Although the causes of pancreatic cancer remain ambiguous, researchers have identified some risk factors that are associated with pancreatic cancer; however, these environmental factors do not account for the majority of cases.

Cigarette Smoking: The most consistent risk factor associated with pancreatic cancer is cigarette smoking. Cigarette smokers are two to three times more likely to develop pancreatic cancer than nonsmokers. Approximately 30% of pancreatic cancers are believed to directly result from smoking.

Age: Research indicates that the risk of pancreatic cancer increases with age. The average age at diagnosis is 70. People under 40 rarely develop pancreatic cancer.

Diet: The results of several clinical studies indicate that individuals who consume a diet high in fat and low in fruits and vegetables and dietary folate may be at an increased risk of pancreatic cancer. Some researchers have reported an association between meat and fish consumption and the risk of pancreatic cancer. This may be related to the carcinogenic and mutagenic effects of heterocyclic aromatic amines present in cooked meat and fish.

Obesity: Research indicates that individuals who are obese are at an increased risk for developing pancreatic cancer. Researchers used data from two United States cohort studies to evaluate the relationship between obesity, physical activity and the risk of pancreatic cancer. The study involved 46,648 men ages 40 to 75 and 117,041 women ages 30 to 55, with10-20 years of follow-up. The results indicated that individuals with a higher body mass index (BMI) had an increased risk of pancreatic cancer compared with individuals with a lower BMI. Furthermore, moderate activity reduced the risk of pancreatic cancer, especially among individuals with a high BMI.

Occupational exposure: Some studies suggest that exposure to petroleum and other chemicals might increase the risk of pancreatic cancer. Petrochemical workers, hairdressers and rubber workers appear to be at an increased risk of pancreatic cancer.

Pancreatitis: Chronic pancreatitis refers to a long-term inflammation of the pancreas. Patients with non-hereditary chronic pancreatitis appear to have an increased incidence of pancreatic cancer; however, the majority of individuals with chronic pancreatitis never develop pancreatic cancer.

Diabetes: There is an increased incidence of pancreatic cancer among patients with diabetes. Individuals with diabetes develop pancreatic cancer twice as often as those who do not have diabetes. Onset of diabetes may herald the appearance of pancreatic cancer, particularly if the diabetes occurs during or beyond age 50. Diabetes is present in 60-80% of patients with pancreatic cancer and the majority of patients were diagnosed within 2 years of the cancer. Patients with diabetes and cancer more often do not have a family history of diabetes. It appears that a subgroup of patients with late onset diabetes who have no family history of diabetes may be at an increased risk. Abnormalities of glucose metabolism in individuals who do not have diabetes are also associated with an increase in pancreatic cancer.

Prevention of Pancreatic Cancer

Cancer is largely a preventable illness. Two-thirds of cancer deaths in the U.S. can be linked to tobacco use, poor diet, obesity, and lack of exercise. All of these factors can be modified. Nevertheless, an awareness of the opportunity to prevent cancer through changes in lifestyle is still under-appreciated.

Since the development of pancreatic cancer is poorly understood, it is difficult to make recommendations for prevention. Currently, the best approach is to avoid the risk factors for this disease and modify diet and lifestyle.

Avoid Smoking: Since cigarette smoking is responsible for 30% of pancreatic cancers, it would be wise to avoid or quit smoking.

Diet: Diet is a fertile area for immediate individual and societal intervention to decrease the risk of developing certain cancers. Numerous studies have provided a wealth of often-contradictory information about the detrimental and protective factors of different foods.

There is convincing evidence that excess body fat substantially increases the risk for many types of cancer. While much of the cancer-related nutrition information cautions against a high-fat diet, the real culprit may be an excess of calories. Studies indicate that there is little, if any, relationship between body fat and fat composition of the diet. These studies show that excessive caloric intake from both fats and carbohydrates lead to the same result of excess body fat. The ideal way to avoid excess body fat is to limit caloric intake and/or balance caloric death in men in the United intake with ample exercise.

It is still important, however, to limit fat intake, as evidence still supports a relationship between cancer and polyunsaturated, saturated and animal fats. Specifically, studies show that high consumption of red meat and dairy products can increase the risk of certain cancers. One strategy for positive dietary change is to replace red meat with chicken, fish, nuts and legumes.

High fruit and vegetable consumption has been associated with a reduced risk for developing at least 10 different cancers. This may be a result of potentially protective factors such as carotenoids, folic acid, vitamin C, flavonoids, phytoestrogens and isothiocyanates. These are often referred to as antioxidants.

There is strong evidence that moderate to high alcohol consumption also increases the risk of certain cancers. One reason for this relationship may be that alcohol interferes with the availability of folic acid. Alcohol in combination with tobacco creates an even greater risk of certain types of cancer.

While researchers have long evaluated the link between diet and all cancers, there also has been research to investigate the link between diet and pancreatic cancer. Recent studies have indicated that reducing intake of well-cooked meat and fish and increasing the intake of fruit and vegetables might be important for preventing pancreatic cancer. In addition, the results of a recent clinical study indicate that a high intake of dietary folate significantly reduces the risk of pancreatic cancer. Some rich sources of dietary folate are leafy greens, turnip greens, dry beans, peas and some fruits and vegetables.

Exercise: Higher levels of physical activity may reduce the incidence of some cancers. According to researchers at Harvard, if the entire population increased their level of physical activity by 30 minutes of brisk walking per day (or the equivalent energy expenditure in other activities), we would observe a 15% reduction in the incidence of colon cancer.

Screening and Early Diagnosis of Pancreatic Cancer

For many types of cancer, progress in the areas of cancer screening and treatment has offered promise for earlier detection and higher cure rates. The term screening refers to the regular use of certain examinations or tests in individuals who do not have any symptoms of a cancer but are at high risk for that cancer. When individuals are at high risk for a type of cancer, this means that they have certain characteristics or exposures, called risk factors that make them more likely to develop that type of cancer than those who do not have these risk factors. The risk factors are different for different types of cancer. An awareness of these risk factors is important because 1) some risk factors can be changed (such as smoking or dietary intake), thus decreasing the risk for developing the associated cancer; and 2) persons who are at high risk for developing a cancer can often undergo regular screening measures that are recommended for that cancer type. Researchers continue to study which characteristics or exposures are associated with an increased risk for various cancers, allowing for the use of more effective prevention, early detection and treatment strategies.

Pancreatic cancer has a high mortality rate because it is difficult to find the disease early. Pancreatic cancer usually does not cause any recognizable symptoms until it is advanced and has spread outside the body. Since the pancreas is deep inside the body, it is difficult to detect tumors during a routine check-up. Currently, there are no screening tests to find this disease early in individuals who have no symptoms.

Currently, computerized tomography (CT) scans are the best way to detect small pancreatic cancers. Endoscopic ultrasound will detect small pancreatic cancers not detected by CT scans. The cancer marker CA 19-9 is sometimes elevated in early cases of pancreatic cancer.

There are no specific recommendations for screening people who are at a high risk for pancreatic cancer. However, one strategy would be to perform a screening CT for persons with familial syndromes associated with an increased risk of pancreatic cancer. In high-risk patients, endoscopic ultrasound is performed if the CT scan is equivocal or negative. A CA 19-9 should be performed on all high-risk patients.

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